|
40-Main drugs interaction
effects
|
||
| albendazole |
+ Cimetidine. + Corticosteroids |
increase the plasma levels of albendazole. |
| + Theophylline | concurrent use is not recommended | |
| AZT | + D4T | concurrent use is to avoid (antagonism) |
| Chloramphenicol | + Clindamycin
+ Erythromycins + Lincomycin |
concurrent use is not recommended |
|
+ phenobarbital + rifampicin |
decrease chloramphenicol concentrations | |
|
+ Penicillins + amoxy + cloxa.. |
bacteriostatic drugs interfere with the bactericidal effects of penicillins. When a rapid bactericidal effect is necessary, it is best to avoid concurrent therapy |
|
| + Mg, Alum., Ca, Fe | Decreased absorption of norflox and cipro | |
| + phenytoin; | decrease the concentration of phenytoin; caution for patients stabilized with phenytoin | |
|
+ Theophylline |
Increased theophyllin concentrations |
|
| Doxycyclin | + Mg, Alum., Ca, Fe | Decreased absorption of doxy |
|
+ phenobarbital + Phenytoin |
decreased doxycycline concentrations; adjustment of doxycycline dosage may be necessary | |
| D4T | + AZT | concurrent use is to avoid (antagonism) |
| + Penicillins | since bacteriostatic drugs may interfere with the bactericidal effect of penicillins in situations where a rapid bactericidal effect is necessary, it is best to avoid concurrent therapy | |
|
+ Chloramphenicol |
concurrent use is not recommended | |
| + Lincomycins | concurrent use is not recommended | |
| + Theophylline | Increased concentration of theophylline | |
| EFV | + Rifampicin | Decreased 25% of EFV concentration. Adjustment of EFV is to be consider See 01-ARV protocols |
| fluconazole | + theophylline | increase concentration of theophylline |
| + Benzodiazepines, clarithromycin, phenitoin, rifabutin |
Fluconazole increase level of benzodiazepines, clarithromycin, phenitoin & rifabutin |
|
| + Rifampicin, rifabutin | Decreased fluco concentration. Adjustment of fluco dosage may be necessary | |
| gentamycin | + streptomycin | concurrent use is not recommended |
| + cloxacillin, ampicillin |
No mixt in seringue Inject genta one hour after or before ampi should be better. |
|
| Itraconazole |
+ phenitoin, digoxin, rifabutin, Theophylline |
Increased phenitoin, digoxin, rifabutin & theophylin concentrations |
| + Rifampicin rifabutin, phenobarbital, isoniazid, phenitoin | Decreased itra concentration | |
| Norfloxacin | + Phenitoin | can decrease concentration of phenytoin |
| + Mg, Alum., Ca, Fe | Decreased absorption of norflox | |
| NVP | ketonazol | Decreased 60% of keto concentration & increased +/-20% of NVP... Avoid association as much as posible |
| rifampicin | Decreased concentration of NVP. Adjustment of NVP must be consider if not possible to avoid the association See 01-ARV protocols | |
| metronidazole | + Alcohol | Disulfiram-like effects such as abdominal cramps, nausea, vomiting, headache, or flushing |
| + Cimetidine | possibly increased serum metronidazole concentrations | |
| + Phenobarbital | phenobarbital may decrease plasma concentration of metro | |
|
+ Phenytoin |
metronidazole may increase phenytoin's plasma concentration | |
| Rifampicin | + prednisolone, dexamethasone, | Decreased concentration of predni & dexa |
|
+ Fluconazole, Ketoconazole, Itraconazole |
Decreased concentration ketonazol & fluconazol & itraconazol. Adjustment of antimycotic dosage may be necessary |
|
| + EFV | Decreased 25% of EFV concentration. Adjustment of EFV is to be consider See 01-ARV protocols | |
| + NVP | Decreased concentration NVP. Adjustment of NVP must be consider if not possible to avoid the association See 01-ARV protocols | |
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_______________________________________
paul yves wery - aidspreventionpro@gmail.com